Exploring bacteria-phage dynamics under antibiotic pressure

Theme: Ecology genetics and evolution 

Description: Phages (viruses that infect bacteria) are emerging as potential allies in the fight against antimicrobial resistance. This project investigates how the eco-evolutionary dynamics of bacteria and phages are impacted when antibiotics are introduced into the system. Students can explore these predator-prey dynamics through mathematical modelling and simulations or by conducting experimental studies using bacterial and phage strains in the lab. The goal is to use ecological perspectives to understand how antibiotic disturbances influence phage efficacy and bacterial resistance, with broad implications for both ecology and clinical applications.

Additional Information: This project is open to students with backgrounds in either experimental biology (microbiology, ecology) or quantitative disciplines (mathematics, computer science). Students can tailor the project to focus on hands-on lab work or in silico modelling (or a combination of both), depending on their skills and interests. Basic experience in microbiology or coding would be helpful but is not essential.

Contact: Dr James Orr