Title: Landscapes of infection: the role of the environment in shaping vector-borne disease transmission
Abstract: Despite the recent gains in reducing the overall global burden of parasites like malaria, vector-borne diseases still account for 17% of all infectious diseases and cause 700,000 deaths in humans annually. Further, climate and land use change are dramatically modifying the landscapes across which vector-borne pathogens are transmitted. Our research applies ecological and evolutionary theory to understand how environmental variation will shape the outcome of the host- pathogen interaction, and the transmission and control of vector-borne diseases now and in the future. I value cross-scale inference, with research questions that span multiple biological scales and mosquito-pathogen systems (Aedes – Zika (ZIKV), Dengue (DENV) viruses, Culex - West Nile virus (WNV), and Anopheles – rodent and human malaria. My research is trans-disciplinary and integrative, adopting theory from the fields of ecology, evolutionary biology, genetics, virology, parasitology, medical entomology, statistics, and immunology. Finally, we use a combination of laboratory experiments, descriptive and experimental studies in the field, and mathematical modeling to answer questions on how environmental variation affects three central areas: 1) the mosquito-pathogen interaction, 2) pathogen transmission dynamics, and 3) evaluating the efficacy of different intervention strategies to answer critical questions on the effects of climate and land use change on current and future vector-borne disease transmission and control.